Opportunity Information: Apply for CDC RFA PS23 0013
The funding opportunity "Assuring Comprehensive Perinatal, Maternal and Infant Health and the Elimination of Perinatal HIV in the United States" (CDC RFA PS23-0013) is a CDC cooperative agreement designed to help the United States achieve and sustain the elimination of perinatal HIV transmission while also improving the overall health and wellbeing of pregnant and postpartum people with HIV, their infants, and individuals living with perinatally acquired HIV. The central idea is that keeping perinatal HIV infections near zero requires ongoing, coordinated public health and clinical action, not only to prevent transmission but also to ensure that prevention and treatment approaches remain safe and effective over time. The project is structured as a close collaboration with CDC over a five-year period of performance and is intended to strengthen national capacity, spread best practices, and support local systems that deliver perinatal HIV prevention and care.
A major deliverable under this NOFO is the creation of a National Resource Center to support implementation of CDC's 2012 "Framework for the Elimination of Perinatal HIV Transmission in the United States." The recipient is expected to function as a national hub that develops, curates, and disseminates practical resources, implementation tools, and technical assistance that can be used by public health programs and clinical providers. Alongside the Resource Center, the recipient will convene a Task Force made up of subject matter experts across public health and clinical disciplines as well as people living with HIV. The Task Force role is to help shape innovative and realistic approaches to improving perinatal, maternal/parental, and infant outcomes, with a strong emphasis on translating what is known into scalable practice and on addressing emerging challenges as standards of care evolve.
The NOFO is grounded in the reality that the United States has made dramatic progress and may have reached elimination levels in 2019, yet continued vigilance is still required. CDC notes that in 2019 there were 32 reports of U.S.-born infants diagnosed with perinatal HIV infection, illustrating both how low the numbers have become and how important it is to prevent any rebound. The opportunity reflects a public health "maintenance and improvement" strategy: building on previous gains, tightening weak points in systems of care and surveillance, and ensuring that prevention efforts remain aligned with contemporary clinical practice, medication regimens, and patient preferences.
The CDC Framework that anchors this work includes six core components that the Resource Center and Task Force will help implement and reinforce nationally. First, it emphasizes reproductive health services, family planning, and prepregnancy care for women of childbearing age with HIV, recognizing that optimal health and viral suppression before conception lowers risk and improves outcomes. Second, it calls for HIV testing and comprehensive case-finding led by public health, so that HIV is identified early and pregnant people are linked to care quickly. Third, it focuses on assuring access to clinical care and behavioral health services for pregnant people with HIV and their infants, acknowledging that mental health, substance use, and social needs can directly affect retention in care and viral suppression. Fourth, it promotes continuous quality improvement in local perinatal HIV systems through case review and community action models such as FIMR-HIV (Fetal and Infant Mortality Review for HIV), which examines cases and near-misses to identify system gaps and drive concrete improvements. Fifth, it highlights research and long-term monitoring to confirm that prevention strategies and modern antiretroviral therapies are not only effective but also safe during conception, pregnancy, and early life. Sixth, it underscores strong HIV surveillance data systems so jurisdictions can evaluate outcomes, identify inequities, and target prevention resources effectively.
The NOFO also draws on lessons from a prior CDC-funded effort (PS17-1712) in which an Elimination of Perinatal HIV Task Force identified key ongoing issues that threaten progress if left unaddressed. One highlighted concern is HIV acquisition during pregnancy from a male partner, which can increase transmission risk and complicate care. In response, the NOFO points to strategies like partner testing during pregnancy, both to protect pregnant people and infants and to connect partners to treatment for their own health. Another priority is ensuring that treatment and preventive interventions are demonstrably safe across pregnancy and lactation, which requires timely data, careful monitoring, and up-to-date clinical guidance as medication options and evidence evolve. The opportunity further recognizes that many U.S. women with HIV are increasingly interested in breastfeeding and that infant feeding recommendations are changing. That creates a need for clear, evidence-informed resources to support shared decision-making and risk reduction, so infant feeding approaches are aligned with both maternal and infant health goals.
A key method for achieving these aims is broad dissemination and capacity building. The recipient is expected to push out training, tools, and technical assistance through large educational and best-practice-sharing networks so that frontline clinicians, health departments, and related programs have ready access to consistent, high-quality guidance. The intended outcome is increased awareness and improved implementation of strategies that maintain elimination of perinatal HIV and strengthen systems that support families affected by HIV. The emphasis is not just on issuing recommendations, but on helping systems actually carry them out through technical assistance, quality improvement processes, and shared learning across jurisdictions.
An additional feature of the NOFO is its potential to create spillover benefits for other perinatal infections. CDC explicitly notes that technical assistance and capacity building to improve perinatal HIV care and prevention systems can create opportunities to apply aspects of the Framework to prevent congenital syphilis or other perinatal infections. If additional funds become available, the program may expand or adapt infrastructure and resources so health care providers and public health professionals can use similar approaches to reduce other congenital or perinatal infections, with congenital syphilis specifically mentioned as a major concern.
From an administrative standpoint, this is a discretionary cooperative agreement from the Department of Health and Human Services, Centers for Disease Control and Prevention (NCHHSTP), with an anticipated single award. Eligibility is broad and includes state, county, and local governments; public and private institutions of higher education; federally recognized tribal governments and other tribal organizations; nonprofits (including 501(c)(3) and non-501(c)(3)); and for-profit organizations (other than small businesses), among others as clarified in the full eligibility text. The NOFO was created April 5, 2023, with an original closing date of June 6, 2023. The award ceiling is listed as 0 in the provided source data (often meaning the ceiling is not specified in that field rather than implying no funding), and the application deadline requires electronic submission by 11:59 pm ET on the due date.
Overall, the opportunity is best understood as a national coordination and implementation grant: it invests in a Resource Center and expert Task Force to help the country hold the line on perinatal HIV elimination, modernize practice as science and patient needs evolve, strengthen surveillance and safety monitoring, and support a workforce capable of responding to persistent and emerging challenges. The practical end goal is not only fewer perinatal HIV infections, but healthier pregnancies, healthier infants, and stronger care and prevention systems for families living with or affected by HIV.Apply for CDC RFA PS23 0013
- The Department of Health and Human Services, Centers for Disease Control - NCHHSTP in the health sector is offering a public funding opportunity titled "Assuring Comprehensive Perinatal, Maternal and Infant Health and the Elimination of Perinatal HIV in the United States" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.939.
- This funding opportunity was created on Apr 05, 2023.
- Applicants must submit their applications by Jun 06, 2023 Electronically submitted applications must be submitted no later than 1159 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Others (see text field entitled Additional Information on Eligibility for clarification), Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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