Opportunity Information: Apply for PAR 20 175
The IDeA Program Infrastructure for Clinical and Translational Research (IDeA-CTR) (U54, clinical trial optional) is a National Institutes of Health (NIH) cooperative agreement opportunity designed to grow and strengthen clinical and translational research capacity in states and jurisdictions that qualify under the NIH Institutional Development Award (IDeA) program. At its core, the program is about closing research infrastructure gaps in historically under-resourced areas so investigators and institutions in IDeA-eligible locations can compete more successfully for external (extramural) clinical and translational research funding and can run higher-quality, more collaborative research programs that respond to local and regional health needs.
This funding supports the creation or expansion of statewide networks and/or multi-state regional networks that can provide shared infrastructure and coordinated services for clinical and translational research. The FOA emphasizes three main objectives. First, it funds the development and enhancement of infrastructure and skilled personnel needed to conduct clinical and translational research effectively in IDeA-eligible jurisdictions. In practice, this often means building or strengthening the systems that make research possible at scale, such as research administration capacity, clinical research operations, regulatory and compliance support, data management resources, and training programs for investigators and research staff. Second, it aims to strengthen the actual clinical and translational research conducted in these states by supporting work that addresses a broad range of health challenges affecting local populations. The expectation is that the network will not be narrowly focused on a single disease area, but instead will be positioned to respond to diverse health priorities that matter to the communities in the region. Third, it prioritizes collaboration by fostering and coordinating partnerships across institutions within the IDeA-CTR network and by linking the network to other organizations and research institutions, which can increase the quality of science, broaden access to expertise, and create clearer pathways for multi-site studies and future grant success.
The mechanism for this opportunity is a cooperative agreement (U54), which generally indicates that NIH will have substantial involvement during the project period compared with a standard grant. The activity category is health, and the program is associated with CFDA number 93.859. The listing indicates the original closing date was 2022-10-07 (PAR-20-175, created 2020-04-24), so it is important for applicants to verify the current status, reissue numbers, or active receipt dates if planning an application now.
Eligibility is broad in terms of organizational types, but it is constrained by the IDeA-eligibility requirement tied to the states and jurisdictions being served. Eligible applicant organizations include various levels of government (state, county, city/township, special district), independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (other than small businesses), and small businesses. It also includes Native American tribal governments (federally recognized) and other Native American tribal organizations. In addition, the FOA explicitly lists several categories of institutions and organizations that may apply, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), as well as faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.
Foreign participation is clearly limited. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply, non-domestic components of U.S. organizations are not eligible, and foreign components (as defined in the NIH Grants Policy Statement) are not allowed. In other words, the program is built to fund U.S.-based infrastructure and networks serving IDeA-eligible U.S. states and jurisdictions, without foreign organizational components embedded in the funded project.
Overall, the opportunity is best understood as an infrastructure-and-network building award for clinical and translational research. Rather than funding a single standalone research project, it is meant to strengthen the foundational capabilities, staffing, coordination, and collaborative ecosystem that allow multiple investigators and institutions in IDeA-eligible areas to develop stronger studies, compete more effectively for NIH and other extramural awards, and address real-world health needs across a region through coordinated clinical and translational research efforts.Apply for PAR 20 175
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "IDeA Program Infrastructure for Clinical and Translational Research (IDeA-CTR)(U54 - Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.859.
- This funding opportunity was created on 2020-04-24.
- Applicants must submit their applications by 2022-10-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the IDeA Program Infrastructure for Clinical and Translational Research (IDeA-CTR) opportunity?
IDeA-CTR is a National Institutes of Health (NIH) cooperative agreement opportunity focused on building and strengthening clinical and translational research capacity in states and jurisdictions that qualify under the NIH Institutional Development Award (IDeA) program. The core idea is to close research infrastructure gaps in historically under-resourced areas so local investigators and institutions can run stronger, more collaborative research programs and compete more successfully for external (extramural) clinical and translational research funding.
What funding mechanism is used for this opportunity?
The mechanism is a U54 cooperative agreement. A cooperative agreement generally means NIH will have substantial involvement during the project period compared with a standard grant.
Are clinical trials required under this FOA?
No. The opportunity is described as "clinical trial optional," meaning clinical trials may be included but are not required based on the information provided.
What is the main purpose of this award?
This award is primarily intended for infrastructure and network building for clinical and translational research. Rather than supporting a single standalone research project, it supports the foundational capabilities, staffing, coordination, and shared systems that enable multiple investigators and institutions to design and run higher-quality research and pursue future extramural funding.
What kinds of networks does this funding support?
The funding supports the creation or expansion of statewide networks and/or multi-state regional networks. These networks are expected to provide shared infrastructure and coordinated services for clinical and translational research across participating institutions.
What are the major objectives emphasized in the FOA?
The FOA emphasizes three main objectives: (1) develop and enhance infrastructure and skilled personnel needed to conduct clinical and translational research effectively in IDeA-eligible jurisdictions; (2) strengthen the clinical and translational research conducted in these states by supporting work that addresses a broad range of health challenges affecting local populations; and (3) foster and coordinate collaboration across institutions within the network and link the network to other organizations and research institutions to improve science, expand access to expertise, and support multi-site studies and future grant success.
What types of infrastructure or capabilities might this award help build or strengthen?
Examples described include research administration capacity, clinical research operations, regulatory and compliance support, data management resources, and training programs for investigators and research staff. More broadly, the emphasis is on building the systems and workforce that make clinical and translational research possible at scale.
Is the research expected to focus on a single disease area?
No. The expectation is that the network will not be narrowly focused on a single disease area. Instead, it should be positioned to respond to diverse health priorities that matter to communities in the region.
How does collaboration factor into this program?
Collaboration is a priority. The program aims to foster and coordinate partnerships across institutions within the IDeA-CTR network and to link the network with other organizations and research institutions. This is intended to improve scientific quality, broaden access to expertise, and create clearer pathways for multi-site studies and future funding success.
Who can apply for this opportunity?
Eligibility includes a wide range of U.S.-based organizational types, but it is constrained by the requirement that the states and jurisdictions being served must be IDeA-eligible. Eligible applicants listed include various levels of government (state, county, city/township, special district), independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (other than small businesses), and small businesses.
Are tribal entities eligible to apply?
Yes. The eligibility list includes Native American tribal governments (federally recognized) and other Native American tribal organizations.
Are minority-serving institutions specifically mentioned as eligible?
Yes. The FOA explicitly lists categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) as eligible to apply.
Are faith-based, community-based, or regional organizations allowed to apply?
Yes. The FOA explicitly includes faith-based or community-based organizations and regional organizations among the categories that may apply.
Are U.S. territories or possessions included in eligibility?
Yes. U.S. territories or possessions are explicitly listed among eligible categories.
Can federal agencies apply?
Yes. The FOA includes eligible federal agencies among the categories that may apply.
Are foreign (non-U.S.) organizations eligible to apply?
No. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply.
Can a U.S. organization include a non-U.S. (non-domestic) component in the project?
No. Non-domestic components of U.S. organizations are not eligible, and foreign components (as defined in the NIH Grants Policy Statement) are not allowed.
What does it mean that this is a "cooperative agreement"?
Based on the description provided, a cooperative agreement indicates that NIH will have substantial involvement during the project period compared with a standard grant mechanism.
What is the activity category and CFDA number associated with this program?
The activity category is health, and the program is associated with CFDA number 93.859.
What is known about the closing date and current status of the opportunity?
The listing notes an original closing date of 2022-10-07 and references PAR-20-175 (created 2020-04-24). Because this date has passed, applicants are expected to verify the current status, including whether there is a reissue number or an active receipt date, if planning to apply now.
Is this award meant to fund a single research project?
No. The opportunity is best understood as an infrastructure-and-network building award. The goal is to strengthen the foundational capabilities and collaborative ecosystem that support multiple studies and investigators, improve competitiveness for future extramural awards, and address local and regional health needs through coordinated clinical and translational research.
What outcomes is the program trying to enable in IDeA-eligible states and jurisdictions?
The program is designed to help investigators and institutions in IDeA-eligible locations compete more successfully for extramural clinical and translational research funding, run higher-quality and more collaborative research programs, and respond to local and regional health needs using shared infrastructure and coordinated services.
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