Opportunity Information: Apply for RFA HL 17 023
The funding opportunity titled "Revision Applications for Regenerative Medicine Innovation Projects (RMIP) (R43/R44)" (Funding Opportunity Number RFA-HL-17-023) is a discretionary NIH grant program that supports competing revision applications to active SBIR awards under the R43/R44 mechanisms. In practical terms, it is not a stand-alone, open-to-anyone SBIR solicitation; it is specifically for small businesses that already hold an active NIH R43 or R44 SBIR grant and want additional funds during the current budget period to expand the scope of work or modify and broaden the approved research protocol. The overall intent is to push forward clinical research efforts in regenerative medicine that rely on adult stem cells, with an emphasis on work that helps the field overcome common, well-recognized barriers to translating regenerative medicine concepts into therapies that are both safe and effective.
A central theme of this FOA is solving development and translation problems that tend to slow regenerative medicine products on their path to patients. The NIH and participating Institutes and Centers, in collaboration with the U.S. Food and Drug Administration, are looking for revisions that add meaningful, targeted activities aimed at issues that matter for real-world product development, especially issues that come up when preparing for or supporting regulatory submissions. That regulatory-facing angle is important: the opportunity is framed to encourage applied, practical advances that improve the evidence base and technical readiness of regenerative medicine products, rather than purely exploratory science that does not connect to manufacturability, control strategies, safety evaluation, or clinical performance.
The areas of interest are described broadly but point to concrete kinds of additions a revision might support. Projects may propose improved tools, methods, standards, or other forms of applied science that strengthen how regenerative medicine products are manufactured and evaluated. This can include work that improves understanding and measurement of manufacturing quality, consistency, and comparability; approaches that enhance product characterization and establish meaningful quality attributes; methods that better assess safety risks; or strategies that clarify and demonstrate effectiveness. The emphasis is on advances that make it easier to evaluate products rigorously, interpret results consistently, and generate data that can credibly support later-stage development decisions and regulatory interactions.
Eligibility is tightly limited. The eligible applicants are small businesses, and the applicant must already have an active R43/R44 SBIR award that can serve as the parent project for the competing revision. Foreign participation is expressly restricted: non-domestic (non-U.S.) entities are not eligible to apply, non-domestic components of U.S. organizations are not eligible, and foreign components (as defined in the NIH Grants Policy Statement) are not allowed. These restrictions mean the proposed revision work must be structured so that all supported components fall within allowable domestic arrangements under NIH policy for this FOA.
From the source details provided, the opportunity was created on April 28, 2017, with an original closing date of June 26, 2017. The sponsoring agency is the National Institutes of Health, and the activity category falls under health-related research (with multiple CFDA numbers listed, reflecting participation across NIH components). An award ceiling and expected number of awards are not specified in the provided data, which often signals that the actual amounts and counts depend on available funds, the quality of submitted revisions, and the priorities of participating NIH Institutes and Centers.
Overall, this FOA is best understood as a mechanism for current NIH SBIR-funded regenerative medicine companies to accelerate or strengthen a running project by adding clinically relevant development work that tackles recognized bottlenecks in adult stem cell-based regenerative medicine, especially work that improves manufacturing control, product quality, safety assessment, and demonstrations of effectiveness in ways that align with regulatory expectations.Apply for RFA HL 17 023
- The National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "Revision Applications for Regenerative Medicine Innovation Projects (RMIP) (R43/R44)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.173, 93.233, 93.242, 93.286, 93.350, 93.837, 93.838, 93.839, 93.840, 93.846, 93.847, 93.853, 93.855, 93.856, 93.866, 93.867.
- This funding opportunity was created on 2017-04-28.
- Applicants must submit their applications by 2017-06-26. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses.
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Applicants who have applied for this opportunity (RFA HL 17 023) also looked into and applied for these:
| Funding Opportunity |
|---|
| Revision Applications for Regenerative Medicine Innovation Projects (RMIP) (R41/R42) Apply for RFA HL 17 024 Funding Number: RFA HL 17 024 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Revision Applications for Regenerative Medicine Innovation Projects (RMIP) (UC4) Apply for RFA HL 17 027 Funding Number: RFA HL 17 027 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| NIDDK Central Repositories Non-renewable Sample Access (X01) Apply for PAR 17 270 Funding Number: PAR 17 270 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Therapeutic Strategies for the Converging TB/T2DM/HIV Epidemics (R01) Apply for PA 17 283 Funding Number: PA 17 283 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Administrative Supplements for Participation in the Concept to Clinic: Commercializing Innovation (C3i) Program (Admin Supp) Apply for PA 17 286 Funding Number: PA 17 286 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Psychological, Behavioral, and Neurocognitive-Focused Ancillary Studies to the Molecular Transducers of Physical Activity in Humans Consortium (MoTrPAC) (U01) Apply for RFA DK 17 009 Funding Number: RFA DK 17 009 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $3,000,000 |
| Center for Identification and Study of Individuals with Atypical Diabetes Mellitus (U54) Apply for RFA DK 17 006 Funding Number: RFA DK 17 006 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Limited Competition for the Continuation of the Chronic Renal Insufficiency Cohort Scientific and Data Coordinating Center (U24) Apply for RFA DK 17 506 Funding Number: RFA DK 17 506 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $2,250,000 |
| Limited Competition for the Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Clinical Centers (U01) Apply for RFA DK 17 505 Funding Number: RFA DK 17 505 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $650,000 |
| Developmental Centers for Interdisciplinary Research in Benign Urology (P20 - Clinical Trials Not Allowed) Apply for RFA DK 17 033 Funding Number: RFA DK 17 033 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $200,000 |
| Investigator-Initiated Clinical Trials Targeting Diseases within the Mission of NIDDK (R01-Clinical Trial Required) Apply for PA 18 330 Funding Number: PA 18 330 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| NIDDK Program Projects (P01 Clinical Trial Optional) Apply for PAR 18 012 Funding Number: PAR 18 012 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $6,250,000 |
| Ancillary Studies to Major Ongoing Clinical Research Studies to Advance Areas of Scientific Interest within the Mission of the NIDDK (R01 Clinical Trial Optional) Apply for PAR 18 042 Funding Number: PAR 18 042 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Metabolic Contributions to the Neurocognitive Complications of Diabetes: Ancillary Studies (R01 Clinical Trial Optional) Apply for PAR 18 051 Funding Number: PAR 18 051 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Secondary Analyses in Obesity, Diabetes and Digestive and Kidney Diseases (R21 Clinical Trial Optional) Apply for PA 18 052 Funding Number: PA 18 052 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $200,000 |
| Pilot and Feasibility Clinical Research Grants in Kidney Diseases (R21 Clinical Trial Optional) Apply for PAR 18 100 Funding Number: PAR 18 100 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $200,000 |
| Pilot and Feasibility Clinical and Translational Research Studies in Digestive Diseases and Nutrition (R21 Clinical Trial Optional) Apply for PA 18 099 Funding Number: PA 18 099 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $200,000 |
| Pilot and Feasibility Clinical Research Grants in Urologic Disorders (R21 Clinical Trial Optional) Apply for PAR 18 101 Funding Number: PAR 18 101 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $200,000 |
| Small Grants for New Investigators to Promote Diversity in Health-Related Research (R21 Clinical Trial Optional) Apply for PAR 18 102 Funding Number: PAR 18 102 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $125,000 |
| Limited Competition: Small Grant Program for NIDDK K01/K08/K23 Recipients (R03 Clinical Trial Optional) Apply for PAR 18 103 Funding Number: PAR 18 103 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $50,000 |
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